The Heegaard Floer homology package of invariants for low-dimensional manifolds has proven extremely successful in solving problems where previous attempts have failed. This talk will focus on some new results along these lines with special attention paid to the smooth knot concordance group. I will give sample results in this context for pretzel knots. Time permitting I will also explain how this relates to new information about the cobordism group of integral homology 3-spheres.